Electrospinning of PEGylated polyamidoamine dendrimer fibers
نویسندگان
چکیده
منابع مشابه
Potential use of polypseudorotaxanes of pegylated polyamidoamine dendrimer with cyclodextrins as novel sustained release systems for DNA.
In this study, we demonstrated the potential use of polypseudorotaxanes (PPRXs) of polyethylene glycol (PEG, molecular weight: 2000)-grafted polyamidoamine dendrimer (PEG-dendrimer) with cyclodextrins (CyDs) as novel sustained release systems for plasmid DNA (pDNA). PEG-dendrimer/pDNA complex formed PPRXs with α-CyD and γ-CyD solutions, but not with β-CyD solution. In the PEG-dendrimer/CyDs PPR...
متن کاملSynthesis, cellular transport, and activity of polyamidoamine dendrimer-methylprednisolone conjugates.
Dendrimers have emerged as promising multifunctional nanomaterials for drug delivery due to their well-defined size and tailorability. We compare two schemes to obtain methylprednisolone (MP)-polyamidoamine dendrimer (PAMAM-G4-OH) conjugate. Glutaric acid (GA) was used as a spacer to facilitate the conjugation. In scheme A, PAMAM-G4-OH was first coupled to GA and then further conjugated with MP...
متن کاملPolypseudorotaxanes of pegylated α-cyclodextrin/polyamidoamine dendrimer conjugate with cyclodextrins as a sustained release system for DNA.
Nonviral gene delivery suffers from a number of limitations including short transgene expression times and low transfection efficiency. In this study, we examined whether polypseudorotaxanes (PPRXs) of polyethylene glycol (PEG, molecular weight: 2,000)-grafted α-cyclodextrin (α-CyD)/polyamidoamine dendrimer conjugate (PEG-α-CDE) with CyDs have the potential for the novel sustained release syste...
متن کاملPolyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue
BACKGROUND The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH(2)) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-NH(2) action in brain tissue on neuronal and astroglial cells. RESULTS In order to describe early mechanisms of G5-NH(2) dendrimer action i...
متن کاملFabrication of Nanoporous Fibers via Bubble Electrospinning
Recently, nanoporous fibers have been caught much attention as the most promising material in nanotechnology. To our knowledge, nanoporous materials have extremely high surface area and are widely used in different fields, such as filtration, radiation protection, catalysis, sensors, tissue engineering, and drug delivery [1-2]. Electrospinning is an effective method, which can fabricate polymer...
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ژورنال
عنوان ژورنال: Materials Science and Engineering: C
سال: 2015
ISSN: 0928-4931
DOI: 10.1016/j.msec.2015.06.025